37 research outputs found
Haptography: Capturing and Recreating the Rich Feel of Real Surfaces
Haptic interfaces, which allow a user to touch virtual and remote environments through a hand-held tool, have opened up exciting new possibilities for applications such as computer-aided design and robot-assisted surgery. Unfortunately, the haptic renderings produced by these systems seldom feel like authentic re-creations of the richly varied surfaces one encounters in the real world. We have thus envisioned the new approach of haptography, or haptic photography, in which an individual quickly records a physical interaction with a real surface and then recreates that experience for a user at a different time and/or place. This paper presents an overview of the goals and methods of haptography, emphasizing the importance of accurately capturing and recreating the high frequency accelerations that occur during tool-mediated interactions. In the capturing domain, we introduce a new texture modeling and synthesis method based on linear prediction applied to acceleration signals recorded from real tool interactions. For recreating, we show a new haptography handle prototype that enables the user of a Phantom Omni to feel fine surface features and textures
Molecular structure and developmental expression of zebrafish atp2a genes
[[abstract]]We isolated two atp2a genes, atp2a1 and atp2a2a, from embryonic zebrafish. Amino acid sequences deduced from zebrafish atp2a genes are aligned with orthologue proteins from other species, the results showed that they share high percentage of identities (82%â94%) and acidic pIs (5.03â5.33). Whole mount in situ hybridization experiments showed that atp2a1 and atp2a2a are maternal inherited genes which can be detected at 1-cell stage embryos and express in the entire animal pole from 6 hours post-fertilization (hpf) to 12 hpf. At the later stages (48â96 hpf), expression of atp2a1 was restricted in head and trunk muscles as well as in some neurons. In contrast to the strongly expression of atp2a1 in head muscle, expression of atp2a2a was detected in head muscle in a fainter manner. In addition, transcripts of atp2a2a were observed in the developing heart during early cardiogenesis. The present studies not only help us to comparatively analyze atp2a genes across species, but also provide useful information about expressions during early embryogenesis that will help in further investigations of functional studies of Atp2a in the future.[[incitationindex]]SCI[[booktype]]çŽ
Strategic directions in constraint programming
An abstract is not available
In vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy
Context : Oral cancers represent a disparate group of tumors with
diverse clinical behavior and chemosensitivity profile. Currently, it
is difficult to predict whether a tumor will respond to chemotherapy
and which drug(s) will achieve the maximum clinical response. Aims : To
study in vitro chemosensitivity profile of oral cancers and to
correlate the in vitro chemosensitivity of oral cancer to clinical
response to chemotherapy. Settings and Design : Prospective study in a
tertiary cancer care center. Methods and Material : We prospectively
studied the chemosensitivity profile of 57 untreated, advanced,
unresectable oral cancers to cisplatin, methotrexate, 5-fluorouracil
and their combinations by using histoculture drug response assay (HDRA)
and correlated them to the clinical response to chemotherapy.
Statistical Analysis Used : Chi Square test. Results : Biopsy samples
were successfully histocultured in 52/57 (91%) cases. Of these 52
evaluable patients, 47 had primary gingivo-buccal cancers and five had
tongue / floor of mouth cancers. Based on the assay, 27 (52%) tumors
were sensitive to cisplatin, 27 (52%) to methotrexate, 24 (46%) to
5-fluorouracil, 38 (73%) to combination of cisplatin and methotrexate
and 36 (69%) to combination of cisplatin and 5-fluorouracil. Of these,
31 patients with good performance status received two cycles of
chemotherapy using one or more of these test drugs. There was a
significant correlation (p=0.03) between the in vitro chemosensitivity
and the clinical response. Negative predictive value of the test was
80%, positive predictive value-69%, sensitivity-79% and specificity
-71%. The overall accuracy of the assay was 74%. Conclusions : We found
HDRA to be a fairly good predictor of chemo-response of oral cancer
In vitro chemosensitivity profile of oral squamous cell cancer and its correlation with clinical response to chemotherapy
Context : Oral cancers represent a disparate group of tumors with
diverse clinical behavior and chemosensitivity profile. Currently, it
is difficult to predict whether a tumor will respond to chemotherapy
and which drug(s) will achieve the maximum clinical response. Aims : To
study in vitro chemosensitivity profile of oral cancers and to
correlate the in vitro chemosensitivity of oral cancer to clinical
response to chemotherapy. Settings and Design : Prospective study in a
tertiary cancer care center. Methods and Material : We prospectively
studied the chemosensitivity profile of 57 untreated, advanced,
unresectable oral cancers to cisplatin, methotrexate, 5-fluorouracil
and their combinations by using histoculture drug response assay (HDRA)
and correlated them to the clinical response to chemotherapy.
Statistical Analysis Used : Chi Square test. Results : Biopsy samples
were successfully histocultured in 52/57 (91%) cases. Of these 52
evaluable patients, 47 had primary gingivo-buccal cancers and five had
tongue / floor of mouth cancers. Based on the assay, 27 (52%) tumors
were sensitive to cisplatin, 27 (52%) to methotrexate, 24 (46%) to
5-fluorouracil, 38 (73%) to combination of cisplatin and methotrexate
and 36 (69%) to combination of cisplatin and 5-fluorouracil. Of these,
31 patients with good performance status received two cycles of
chemotherapy using one or more of these test drugs. There was a
significant correlation (p=0.03) between the in vitro chemosensitivity
and the clinical response. Negative predictive value of the test was
80%, positive predictive value-69%, sensitivity-79% and specificity
-71%. The overall accuracy of the assay was 74%. Conclusions : We found
HDRA to be a fairly good predictor of chemo-response of oral cancer